, Acute HIV infection is a transient symptomatic illness that can be identified in 40–90% of cases of new HIV infection. It is characterized by a high rate of HIV replication, high titers of virus in blood and lymphoid organs (up to several million copies of HIV RNA per cubic millimeter of plasma), and initiation of an HIV-specific immune response. The amount of virus present in blood and tissues begins to fall after the appearance of cytotoxic (“killer”) lymphocytes that specifically react with HIV antigens; the vigor of this response varies among individuals and is associated with subsequent rate of disease progression . A pool of persistently infected CD4 cells (“latent reservoirs”) emerges early in the course of HIV infection and persists indefinitely .
Symptoms have been identified 5–30 days after a recognized exposure to HIV .The signs and symptoms of acute HIV infection are not specific; fever, fatigue, rash, headache, homeopathy, pharyngitis, mild
gastrointestinal upset, night sweats, aseptic meningitis, and oral ulcerations are most frequently reported. Because the clinical signs of acute HIV infection resemble those of many acute viral illnesses, the correct diagnosis is often missed. Because early treatment at the time of acute infection is actively being investigated (Rosenberg, 2000) (see Chapter IV on Primary Medical Care), early suspicion of and evaluation for HIV infection should be encouraged .
gastrointestinal upset, night sweats, aseptic meningitis, and oral ulcerations are most frequently reported. Because the clinical signs of acute HIV infection resemble those of many acute viral illnesses, the correct diagnosis is often missed. Because early treatment at the time of acute infection is actively being investigated (Rosenberg, 2000) (see Chapter IV on Primary Medical Care), early suspicion of and evaluation for HIV infection should be encouraged .
No comments:
Post a Comment